岡山医学会雑誌
Online ISSN : 1882-4528
Print ISSN : 0030-1558
曝気法における脳浮腫の実験的研究
第2編 メチルプレドニゾロン大量投与の抗脳浮腫作用と局所神経機能障害におよぼす影響
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1988 年 100 巻 1-2 号 p. 23-29

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The present study was carried out to evaluate the effects of methylprednisolone (MP, 30 mg/kg) on brain edema and subcortical neural activity in anaesthetized cats with the cerebral cortex exposed to the air. MP was administered intravenously immediately after cortical exposure. After treatment with MP, significant reduction of edema was demonstrated in the primary sensorimotor cortex, white matter, and thalamus compared to the control. MP significantly increased local blood flow in the cortex and thalamus, but not in the white matter, and also protected the cortex against the ischemic suppression of the direct cortical response. However, MP did not affect the prolongation of the N1 latency of the somatosensory evoked response. The effect of steroids on cortical neural activity, including their beneficial effect on cortical edema and ischemia, may explain the rapid clinical improvement following administration of steroids.

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