抄録
Activities of aromatase cytochrome p-450 in columnar epithelial region (CE), squamous epithelial region (SE), and connective tissue (CT) of uterine cervix, and endometrium (EM) during the menstrual cycle were determined using [4-14C] and [1β-3H] androstenedione. Aromatase activity in the proliferative phase (n=8) was 15.0±7.9, 10.9±10.3, 9.4±10.6, and 8.0±7.3 (mean±SD) fmol/h/mg protein in CE, SE, CT, and EM, respectively, and aromatase activity in the secretory phase (n=6) was 31.5±7.6, 19.1±7.1, 5.6±4.6, and 6.3±1.5 fmol/h/mg protein, respectively. No significant difference was detected in the aromatase activity between any two regions in the proliferative phase. On the other hand, in the secretory phase, the aromatase activity was significantly higher in CE than in any other region (p<0.05), and significantly higher in SE than in CT or EM (p<0.05) There was no significant difference in aromatase activity between CT and EM. The aromatase activity in CE was significantly higher in the secretory phase than in the proliferative phase (p<0.05), but no significant difference was observed in other regions.
