非ホジキンリンパ腫におけるCHOPB-POEMB交替療法に関する研究-中・高悪性度の組織型についての検討
1993 年 105 巻 11-12 号 p. 891-901
詳細
1993 年 105 巻 11-12 号 p. 891-901
Between 1986 and 1991, 45 patients with intermediate- or high-grade non-Hodgkin's lymphoma, including 30 patient with large cell lymphoma (including both diffuse large cell and large cell, immunoblastic), were treated with CHOPB-POEMB chemotherapy. The regimen consisted POEMB (a combination of prednisolone, vincristine, etoposide and bleomycin) alternating every 3 weeks with a variant of CHOP-Bleo. None of the patients had received prior chemotherapy. The overall complete response (CR) rate was 80% and 20 patients (57%) were disease free for a median follow up time of 48 months.
In cases of large cell lymphoma, the CR rate and disease free rate were 73% and 65%, respectively. Toxic effects were well-tolerated. Alternating CHOPB-POEMB was useful for treatment of intermediate- or high-grade non-Hodgkin's lymphomas.
