抗原捕捉免疫測定法による抗アシアロ糖タンパク質受容体抗体の検出-自己免疫性肝疾患における臨床的意義-
2002 年 114 巻 2 号 p. 159-165
詳細
2002 年 114 巻 2 号 p. 159-165
In the development of autoimmune chronic active hepatitis (AIH), the pathogenic relevance of autoimmune responses against asialoglycoprotein receptor (ASGPR) has been implicated. We have previously developed a capture enzyme-linked immunosorbent assay (ELISA) for detection of anti-ASGPR antibodies and found a high prevalence of anti-ASGPR antibodies in AIH and primary biliary cirrhosis (PBC). In this study, to clarify the clinical significance of the measurement of anti-ASGPR antibodies in autoimmune liver diseases we studied correlations between the titer of anti-ASGPR antibody and various laboratory data, activity and stage of the disease. We also determined the isotype of the anti-ASGPR antibody. In AIH, the anti-ASGPR antibody titer was positively correlated with serum γ-globulin and IgM values, but not with serum transaminase. The anti-ASGPR antibody titer in histologicallyactive disease with piecemeal necrosis was significantly higher than that in quiescent disease. The most common Isotype of anti-ASGPR antibodies detected in active AIH was IgM. We encountered a case of AIH where the titer of IgM anti-ASGPR antibody decreased by induction of remission with steroid therapy. These results suggest that the measurement of IgM isotype anti-ASGPR antibody might be useful for the evaluation of disease activity and effects of therapy in AIH patients.
