岡山医学会雑誌
Online ISSN : 1882-4528
Print ISSN : 0030-1558
P32による実験的日本腦炎の研究(其の一)
日本脳炎ウイルス脳内接種マウス臟器(肺,脾及び腎)に於ける核酸代謝のSchneider法による研究
内田 豊
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ジャーナル フリー

1956 年 68 巻 5 号 p. 333-340

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Phosphorus metabolism in lung, spleen and kidney was investigated in connection with the virus infection. For this purpose radioactive P32 was employed as the tracer and its incorporation and distribution were examined on three organs of the infected mouse.
The mice were intracerberally inoculated and various hours after the inoculation they were intraperitoneally injected with adequate amounts of P32. Twelve hours after the injection of P32 each of the lung, spleen and the kidney was fractionated by Schneider's method, respectively.
Acid soluble fractions, phospholipid fractions and nucleic acid-phospho protein fractions were obtained and examined on their radioactivities.
Remarkable incorporation of P32 to the nucleic acid phospho protein fractions of lung, spleen and kidney of the infected mouse was observed just at the incubation stage or the so-called visceral phase of Japanese B Encephalitis.
This seems to imply that rapid metabolic changes in nucleic acid and phospho protein or other related substances take place in these organs at the visceral phase oo Japanese B Encephalitis.

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