岡山医学会雑誌
Online ISSN : 1882-4528
Print ISSN : 0030-1558
重積痙攣家兎脳髓のグルタミン酸に関する実験的研究
第1編 重積痙攣家兎脳髄における遊離アミノ窒素及びグルタミン酸の変動について
友沢 久雄
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ジャーナル フリー

1956 年 68 巻 7 号 p. 935-943

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The changes of the amount of free amino-nitrogen and glutamic acid were investigated in the rabbits brain with repeated convulsions caused by hexogen.
The free amino-nitrogen was measured by Van-Slyke-Neil gasmetric apparatus, and the glutamic acid was measured by Warburg gasmetric apparatus with glutamic acid decarboxylase. The results were as follows.
Normal Rabbits Brain During Repeated Convulsions 20-24 Hours after Repeated Convulsions
Free Amino-nitrogen 0.4553mg/g 0.3006mg/g 0.3324mg/g
Glutamic acid 1.5501mg/g 0.9543mg/g 1.2425mg/g
The free amino-nitrogen as well as the glutamic acid were the most in the normal brain and the least during the repeated convulsion, and they showed a certain increase at 20-24 hours after the repeated convulsions compared with those during the convulsions, but still apart from the normal.
Glycolysis was depressed by sodium glutamate in the normal rabbits brain which had enough glutamic acid, but the glycolysis was rather accelerated by sodium glutamate in the rabbits brain which had repeated convulsions and thus scarce glutamic acid, when the sodium glutamate was added to the irrigating fluid of the vessels in the brain and then the glycolysis was measured in each irrigating fluid before and after irrigation.
Therefore, it could be concluded that sodium glutamate has the effect of regulation to keep the normal and moderate glycolysis in the brain.

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