抗生物質の試験管内相互作用に関する研究

第三編 Penicillin, Streptomycin, Aureomycin, Chloromycetin耐性葡萄球菌寺島株に対する各抗生剤の相互作用竝に交差耐性について

抄録

In this report, the effect of combinative administrations of antibiotics on the drugresistant strains of Staphylococcus aureus (Terashima), and the acquisition of cross-resistance were also studied. The results are as follows:
1) To the 5 γ/ml and 10 γ/ml of penicillin-resistan strain, the following combinations are all co-operative; penicillin and streptomycin, penicillin and aureomycin, penicillin and terramycin, and penicillin and chloromycetin.
2) To the 50 γ/ml and 100 γ/ml of streptomycin-resistant strain, the following combinations are all co-operative; streptomycin and penicillin, streptomycin and chloromycetin, streptomycin and terramycin, and streptomycin and aureomycin.
3) To the 10 γ/ml of aureomycin-resistant strain, the following combinative administrations are all co-operative; aureomycin and penicillin, aureomycin and streptomycin, aureomycin and terramycin, and aureomycin and chloromycetin.
4) To the 5 γ/ml of chloromycetin-resistant strain, the following combinative administrations are all co-operative; chloromycetin and penicillin, chloromycetin and streptomycin, chloromycetin and terramycin, and chloromycetin and aureomycin.
5) The penicillin-resistant strain is not resistant to streptomycin, aureomycin, terramycin and chloromycetin.
6) The streptomycin-resistant strain is not resistant to penicillin, aureomycin, terramycin and chloromycetin.
7) The aureomycin-resistant strain is not resistant to penicillin, streptomycin and chloromycetin, but is resistant to terramycin.
8) The chloromycetin-resistant strain is not resistant to penicillin and streptomycin, but is resistant to aureomycin and terramycin.