1957 年 69 巻 5 号 p. 1341-1354
The author has studies gross and histological changes in the anorectal region of rabbit, in which Antihemorrhoid was injected, after ligature of the V. rectalis cranialis and resulting congestion.
1) In 5% solution produced exudative inflammation not accompanying with necrosis and showed atrophy on the 7th. day, after subsiding of reactive inflammation.
2) In 15% solution produced partial necrosis and a granulation tissue was replaced after its falling off, disappeared inflammation on the 12th to 15th day.
3) In 25% solution produced extensive necrosis which was followed by organization and cicatrization after 15 to 21 days.
4) Thrombophlebitis was not observed in the caudal part of V. rectalis cranialis ligated.
The experimental results will allow to say that this drug is effective and safe to use.