パラチオン中毒に関する研究

第2編 肝障碍家兎に於けるパラチオン中毒

抄録

Using the rabbits whose liver had been been injured with injection of 20% CCl₄ in oliveoil (1 cc/kg) every two days and administering parathion 24 hours after the third CCl₄ injection, the following results were obtained:
1) In rabbitts with injured liver serum cholinesterase activity reached its maximum 24 hours after the 3rd CCl₄ injection and returned to the original level, showing the improvement in the function of bromsulfalein excretion.
2) In the group with parathion injection 3 mg/kg each, serum cholinesterase activity was inhibited to the highest degree 3-6 hours after the parathion injection as in the healthy rabbits, but the slackening of cholinesterase activity in the injured was less marked than in the healthy, and lasted longer.
3) The LD₅₀ in the rabbits with injured liver was 3.88 (2.645.70) mg/kg, while the LD₅₀ in the healthy rabbits is 10 mg/kg.
4) In the injured rabbits parathion had no influence upon the recovery of the function of bromsulfalein excretion.