肝硬変に対する肝動脈結紮術の実験的研究

第2編 実験的肝硬変の肝動脈結紮の影響主として肝組織像について

抄録

1) Incidence of mortality and morbidity following ligation of hepatic artery are less in rats in whom cirrhosis of the liver has been produced by a long-term injection of carbon tetrachloride than in normal rats.
2) Decrease of ascites and disappearance of dilatated vein occure more faster in rats with cirrhosis who had hepatic artery ligation than in control group without ligation of hepatic artery.
3) Gradual restoration of damaged liver tissue develops in both ligation group and control. Dilatation of branches of portal vein and interlobular vein, and intralobular hemorrhage are found and occasionally, marked central degenerative changes are seen in the former group. However, no difference were noticeable in degree of restoration between both groups after a given period (60 days).
4) Polysaccharide in liver cell decreases at initial stage and then increases gradually in both groups. However, distribution of polysaccharide is different between both groups when it decreases. In the control group polysaccharide are distributed scattered in lobules. However, in the rats with ligation of hepatic artery decrease of polysaccharide is more marked and temporarily disappears in most lobules except localized accmulation in some parts, and which is followed by relatively rapid increase.
5) Fatty degeneration decreases in both groups and finally disappears. Central fatty degeneration increases temoporarily and later decreases in some cases of the ligation group.