胃疾患における胃液蛋白並びに胃組織蛋白の濾紙電気泳動像に関する研究

第2篇 胃疾患における胃組織蛋白の濾紙電気泳動像に関する研究

抄録

The fraction in filter paper electrophoresis and protein contents of gastric wall tissue protein in resected stomachs from various gastric patients were measured. Moreover using dogs, protein construction of gastric wall from lesser curvature side of the pylorus, which is a predilection part of various gastric diseases, was examined to know its local disposition.
1) The filter paper electrophoresis of normal human gastric wall tissue protein is divided into 6 fractions both in mucous and muscle layers at every part of the stomach. In dogs, it was divided into 5 fractions.
2) At filter paper electrophoresis the first fraction is high both in mucous and muscle layer. Especially it is marked in corpus and pylorus.
3) In cancer tissues the first fraction is not admitted or it is extremely low, but the sixth fraction is high as that in the noncancerous part. The fractions are usually not stable.
4) The soluble protein content of normal gastric wall tissue muscle layer is at least in corpus and most in pylorus. On the contrary that of mucous layer is less in pylorus.
5) Both soluble and total protein content in gastric cancer tissue show lower values compared with those of normal, gastritis and gastric ulcer.
6) Comparing the soluble protein content of every part of normal gastric wall in dogs, the protein content exists apparently more in mucous layer than in muscle layer at sides of lesser curvature of fundus and major curvature of corpus. On the contrary, at the sides of lesser curvature of corpus and pylorus, it exsists less in mucous than in muscle layer. The latter two parts agree with the predilection part of gastritit, ulcer and cancer and they are supposed to be one of the local dispositions.