紫外線照射によるR. tsutsugamushiの不活化に関する研究
第2編 不活化されたR. tsutsugamushiの血清学的諸性状について
1959 年 71 巻 3-1 号 p. 1113-1124
詳細
1959 年 71 巻 3-1 号 p. 1113-1124
In order to study the immune effect of the rickettsiae inactivated by ultra-violet irradiation, the author performed immune experiments in rabbits. The results are briefly summarized as follows:
1) The liver and spleen emulsion of mice infected with Kagawa strain of R. tsutsugamushi was inactivated by ultra-violet irradiation as reported in part I. Inoculation of thus inactivated rikettsiae into rabbits produced neutralization antibody to some extent, but the neutralization effect was low and could not prevent the attack of ricketsiae.
2) Filling up of the reticuloendotherial system by injection of indian ink or by addition of adjuvant could not raise the neutralization effect.
3) In the neutralization test by inoculation of the mixture of R. tsutsugamushi antisera, inactivated rickettsiae and active rickettsiae, the virulence of active rickettsiae was enhanced, and the neutralization effect was lowered. In the neutralization test with the antisera, which had been previously absorbed by inactivated rickettsiae, and active rickettsiae, the virulence of active rickettsiae was enhancedand the neutralization effect was lowered; this fact suggests the absorption of antibody by the inactivated rickettsiae.
