胃癌と鉄代謝
第2編 癌エキスの鉄代謝に及ぼす影響についての実験的研究
1959 年 71 巻 3-1 号 p. 961-970
詳細
1959 年 71 巻 3-1 号 p. 961-970
Cancer extract and gastric wall extract as control were injected intravenously on adult dogs, and examined iron absorption through intestine, resulting anemia, and liver iron by reduced iron loadinh test.
1) On reduced iron loading, the fluctuation curve of serum iron was highest in dogs injected gastric wall extract, slightly less in normal dogs, lowest in dogs injected cancer extract.
2) on pouring of sulfuric iron into the intestinal canal iron absorption value was highest after 30 minutes. in dogs injected cancer extract the value was lower than in normal dogs.
3) In dogs after subsequent injection of cancer or gastric wall extract, R. B. C., Hb and serum iron level were reduced day after day, especially marked in dogs injected cancer extract. Total liver non-hemin iron and ferritin were increased 3 to 6 days after injection and decreased later. The fluctuation was marked in cancer extract, increasing significantly. On 9th day those values ware restored to normal in the control group, though remained lower in cancer extract.
