無カタラーゼ血液症に出現する高原氏病の成因についての実験的研究

第I編 過酸化水素注射後のアヒル口蓋粘膜の組織化学的研究

抄録

In acatalasemia, specific oral gangrene called Takahara's desease is often encountered. With the purpose to elucidate the causative factor of this gangrene, animal experiments were carried out. Namely, ducks having only a trace amount of catalase in their blood were used as experimental animals and for the control, rabbits were served for the experiments. By injecting various. concentration of hydrogen peroxide in isotonic saline under the mucous membrane of the palate in each animal, macroscopical investigation as well as histochemical investigation of activity of succinic dehydrogenase system were conducted at a fixed time after the injection.
The results obtained were as follows.
1) Macroscopically in the ducks there appeared redness, swelling, coat and gangrene resembling the one observable in acatalasemia cases, but in the rabbits redness and swelling were slightly observed.
2) The histochemical findings observed in experiments in the ducks showed marked decrease in activity of succinic dehydrogenase system in mucous epithel, blood vessel wall and muscle compared to that observed in rabbits.
It is assumed that the facts described above proves that the succinic dehydrogenase system possessing a strong affinity to hydrogen peroxide are affected in ducks more strongly by the oxidative action of hydrogen peroxide than in the case of rabbits.