血液疾患並びに悪性腫瘍のアミノ酸代謝に関する研究

第I編 Thin-layer chromatographyによるアミノ酸分析法とその応用

抄録

(1) Approximately 20 kinds of amino acids were found in pleural fluid or ascites of patients with malignant tumor in the terminal stage. Among those, found were increased amount of essential amino acids such as Leu, Ileu, Thr, Val, Arg and Lys, a few unidentified ninhydrin-positive spots, and a spot suggestive of β-amino-isobutyric acid. From the fact that, those are important amino acids which constitute body protein, an increased amount of the amino acids in the pleural fluid and ascites are though to indicate the leak of the inversingly destructed body proteins in the terminal stage of malignancy.
(2) Pro, Glu, Lys, and Orn were increased and Met decreased in the gastric juice of patients with stomach cancer. These supposedly resulted from qualitative abnormality of glandular epiterial cells terminating to malignant proliferation.
(3) Fractionation of bone marrow cells.
Concertration of amino acids was increased in acute leukemia, whether lymphatic or myelogenous.
Amino acids which constitute nucleas were different in acute and chronic leukemia.
If these result reflect the pathogenesis of leukemia, it follows, interestingly enough, that acute and chronic leukemia have different cause.