岡山医学会雑誌
Online ISSN : 1882-4528
Print ISSN : 0030-1558
血清α-Fetoprotein濃度上昇の臨床的意義に関する研究第2編 Computer Scintigram及びα-Fetoproteinの肝癌診断への応用
田中 義淳
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ジャーナル フリー

1976 年 88 巻 3-4 号 p. 285-295

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Twenty two cases with primary hepatocellular carcinoma, 6 cases with cholangiocellular carcinoma and 12 cases with metastatic liver cancer were examined by scintiphotography using scintillation camera with 99mTc radio colloid (99mTc-sulfur colloid, 99mTc-staneous colloid or 99mTc-phytate) and 67Ga-citrate or 67Ga-malate. In addition to the conventional analysis of hepatic scintiphotography, the data were also fed into computer system and stored in the memory (64×64 memory). Application of Fourier transforms and the interative approximation according to Iinuma's method to the averaged matrix data were performed to restore true information of hepatic image. The subtraction scintigram was obtained by subtracting 99mTc activity from 67Ga activity in each matrix data treated with computer focusing.
Twenty of 22 cases of patients with hepatocellular carcinoma were diagnosed by liver by liver scintiphotography with 99mTc radio colloid, but one of 2 cases undetectable on conventional scintigram. In the remaining one case, diagnosis was accomplished by continuous increase of serum α-fetoprotein. One case of metastatic liver cancer invisible on conventional scintiphotography were diagnosed by means of computer scintigraphy and subtraction scintigraphy. This is indicated that more cases of hepatic carcinoma can be deagnosed by the application of serial determination of serum α-fetoprotein, computer scintigraphy and subtraction scintigraphy simultaneously.

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