肝疾患における肝組織の免疫組織学的研究

第1編 組織内免疫グロブリン(IgG, IgA, IgM)の局在について

抄録

For the purpose to elucidate immunopathological significance of immunoglobulin in liver tissue of various liver diseases, localizations of three kinds of immunoglobulins, namely IgG, IgA and IgM, in liver tissue from 30 patients with chronic hepatitis (18 cases with history of blood transfusion and 12 cases without history of blood transfusion) were studied by direct fluorescent antibody technique. The localization of the specific HBs (HB surface) antibody in liver tissue from 5 patients examined HBs antigen in those sera, were observed by the use of direct fluorescent antigen method.
IgG in immunoglobulins was localized as a pattern of immune deposits in the following areas, where the focal necrosis, piecemeal necrosis, destruction of the limiting plate, and the exudative areas of sinusoidal capillary walls, peripheral regions of the portal veins and central veins were observed. Also IgG in immunoglobulins was localized in the cytoplasm of Kupffer's cells as a phagocytic granule and in the mononuclear cell as a produced pattern in portal areas.
Intensities of specific fluorescence of IgA and IgM were observed in a lesser degree than that of IgG in the same area.
Localizations of HBs antibody was found in the areas where the infiltration of plasma cells, destruction of limiting plate and piecemeal necrosis were observed in the patients with positive HBs antigen in the serum.