The Effects of NF-κB Inhibitors on Bone Formation

Abstract

The transcription factor nuclear factor-κB (NF-κB) plays a pivotal role in the regulation of the immune system, including the inflammatory response. The NF-κB signaling pathways also play an important role in bone homeostasis, especially in regard to osteoclast differentiation. The role of NF-κB in bone formation, however, remains to be fully elucidated. In this review, the effects of NF-κB inhibitors, focusing on bone formation, are described based on our findings.