In this study, we examined pathologically the effects of ammonium oxofluoromolybdate ((NH4)2MoO2F4) on rats. This agent was devised as a new drug for prevention of dental caries.
Eighty animals were administered perorally with 25mg, 50mg, 100mg or 125mg of (NH4)2MoO2F4/-kg b.w./day for 28 days. Twenty other animals administered with distilled water were used as a control group.
Pathological changes were observed chiefly in the 100mg and 125mg/kg b. w. groups. The results were as follows:
1) growth retardation and anorexia
2) decrease of hair brightness
3) diarrhea during early period of administration
4) decrease in number of erythrocytes and low hemoglobin level
5) high molybdenum level in the blood and urine
6) decrease in number of acidophils in the hypophysis
7) less staining (HE) and balooning degeneration of the liver cells located chiefly in the peripheral zone of the lobule
8) degeneration of convoluted tubles of the renal cortex
9) dilatation of the rostral part of stomach (thinning of gastri c wall)
10) pigmentation on the mucosal surface of the rostral part of stom ach
11) degeneration, necrosis and atrophy of the glandular epith elium of stomach
12) degeneration, necrosis and atrophy of villi of the intestine
13) increase of debris of degenerating sperm in the testis
Among those changes mentioned above, liver and gastrointestinal disorders were most serious.
Histopathological findings in this investigation were almost similar to those of other experiments in which animals were given large dosages of NaF, Ag (NH3)2F or (NH4)2MoO4.