2001 Volume 50 Issue 4 Pages 255-257
Inhibitory effects of food phenolics including synthetic antioxidants, genistein, catechins and quercetin on the binding of radiolabeled estradiol to human estrogen receptor α were examined, and were compared with that of phenolic bisphenol A. While inhibitory activity of bisphenol A was 1/100 fold that of the control cold estradiol, inhibitory activities of the food phenolics were less than 1/3000 that of the control cold estradiol. The results do not suggest endocrine deiscupting properties of food phenolics including synthetic antioxidants, catechins and flavonoids.