2002 年 51 巻 5 号 p. 365-369
(−)-Hydroxycitric acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss in humans, and is the principal acid in the rinds of Garcinia cambogia, a fruit native to Asia. NOAEL (no-observed-adverse-effect level) of G. cambogia extract was determined in the present study and examination was made of adverse effects of high-dose administration to 44 healthy volunteers who had received 4000 mg HCA. No adverse effect was noted in any subjects. NOAEL of G. cambogia extract was estimated as more than 4000 mg HCA. Sequential-high-doses administration study was condusted in subjects who had been given 3000 mg HCA daily for 10 days. Blood samples were used to obtain clinical data before and after treatment. The clinical data were essentially the same for either time. G. cambogia extract at more than 3000 mg HCA may be considered safe for healthy persons.