2006 年 55 巻 6 号 p. 283-289
Male SHR/NDmc-cp rats aged 10 weeks were fed ad libitum a powdered diet (AIN93G; no fat) containing 7 wt% of fresh virgin soybean oil (control) or used frying oil recovered from Japanese food manufacturing companies (recovered oil) for 8 weeks and subjected to anthropometric measurements, hematological analyses, and histological evaluations of liver and kidneys. All of the rats grew well, and no gross symptoms attributable to recovered oil were observed. The experimental group showed a tendency toward higher body weight gain and higher amounts of fecal excretion than the control group in spite of decreased consumption of the diet. In the serum of the experimental group, remarkably high levels of glucose, triacylglycerol, and free fatty acids were detected. Microscopic observations indicated frequent lesions in renal cells and nuclear losses of tubular epithelium in the experimental group. Thus, the high body weight gain seems to be due to water accumulation in the body. It is not clear, however, why recovered oil increased serum glucose level. No consistent effects on blood pressure or heart rate were observed.
