Journal of Oleo Science
Online ISSN : 1347-3352
Print ISSN : 1345-8957
Detergents, Surfactants, Interface and Colloid
Effects of β-Sitosteryl Sulfate on the Hydration Behavior of Dipalmitoylphosphatidylcholine
Ananda KafleTakeshi MisonoAvinash BhadaniMasaaki AkamatsuKenichi SakaiChihiro KaiseTeruhisa KanekoHideki Sakai
Author information

2018 Volume 67 Issue 6 Pages 763-771


We investigated the hydration behavior of dipalmitoylphosphatidylcholine (DPPC) bilayers containing sodium β-sitosteryl sulfate (PSO4). PSO4 was found to enhance hydration in the headgroup region of DPPC bilayers. Therefore, with the incorporation of PSO4 into DPPC membranes, the amount of water required to reach the fully hydrated state was enhanced as indicated by the constant values of the main phase transition temperature (Tm) and the bilayer repeat distance (d). For example, with the addition of 20 mol% of PSO4, the saturation point was shifted to ~70 wt% water compared to ~40 wt% for pure DPPC and 47 wt% for DPPC-cholesterol. The effectiveness of PSO4 in fluidizing the membrane and enhancing its hydration state can be useful in the pharmaceutical and cosmetic industries.

Information related to the author
© 2018 by Japan Oil Chemists' Society
Previous article Next article