Aggregation Behavior of Antipsychotic Drug under the Influence of Bile Salt in Aqueous/Urea Solution

Abstract

The self-assembly of pharmaceutical amphiphiles is an important area of research because of the involvement of these amphiphiles in physiological processes. The mixed micellization behavior of antipsychotic drug (chlorpromazine hydrochloride, CPZ) in the presence of bile salt (sodium cholate, SC) was studied by surface tension and fluorescence techniques in aqueous/urea solution. The output of the study has been analyzed by using different models (Clint, Rubingh, and Motomura) for mixed amphiphilic systems. The attractive or synergistic interactions between these two amphiphiles in water/urea were confirmed by the obtained data. Various thermodynamic parameters for the mixed micellization process have been computed and discussed.