変敗油の毒性 (第14報)
熱酸化重合油の投与とラット組織のリン脂質に対するトコフェロール補充の影響
1974 年 23 巻 6 号 p. 375-379
詳細
1974 年 23 巻 6 号 p. 375-379
When fresh soybean oil (FO) is heated in the presence of air, tocopherol (Toc) in the oil is decreasing. In the previous papers, the authors reported that the effect of Toc on the prevention of toxicity induced by thermally oxidized oil (TO). The present paper deals the effect of Toc on phospholipids and stabillity of erythrocytes of rats fed with TO.
The results indicated that phosphatidyl choline (PC) in liver, kidney and testicle of rats fed with TO decreased and phosphatidyl ethanolamine (PE) and phosphatidyl serine (PS) increased slightly. The amounts of polyunsaturated fatty acids in phospholipids or each phospholipid such as PE, PC, PS and PI* in rat tissues fed with TO decreased less than those fed with FO or TO and Toc.
Percentage of erythrocyte hemolysis of rats fed with TO was higher than those of FO or TO with Toc. From these data, it was clearly found that component or fatty acid composition of phospholipids and stability of erythrocytes in rats fed with TO were characteristially improved by the addition of Toc.
* Phosphatidyl inositol
