多塩基酸型バィオサーファクタントの分子集合形態のpH依存性変換

抄録

By polarized and fluorescent microscopy and TEM, the octyl-and heptylamine salts of both spiculisporic acid (4, 5-dicarboxy-4-pentadecanolide, S-acid) produced by Penicillium spiculisporum and its open-ring acid (3-hydroxy-1, 3, 4-tetradecanetricarboxylic acid. O-acid) were confirmed to form vesicles in water at about pH 6.0, lipid particles at pH 6.36.6 and micelles at about pH 7.0. It showed be pointed out that these alkylamine salts of S-acid and O-acid reversibly change their conversion equilibria among their molecular aggregates within considerably narrow pH differences. Also, these salts correspond to polyalkyl amphiphiles introduced by ionic bonding and thus may possibly adapt themselves to the conversion of their aggregating comformation. In fact, it was found that the chemically modified polyalkyl derivatives of O-acid and agaricic acid (produced by Polyporous officinalis) each having one more alkyl chain formed only vesicles as molecular aggregates. This pH-sensitive or pH-detecting conversion may possibly find use in sensing and separating systems.