Regulation of Lipogenic Enzyme Induction

Abstract

Although dietary carbohydrate, protein and fat contributed to the induction of lipogenic enzymes in a similar direction, the regulation mechanisms were individually different. Acetyl-CoA carboxylase and malic enzyme were carbohydrate-dependent, whereas glucose-6-phosphate dehydrogenase was rather protein-dependent. Both carbohydrate and protein were required for fatty acid synthetase induction. Concerning malic enzyme, the transcriptional rates were increased by feeding various diets to fasted rats, but the increases were not significantly different among the nutrients. On feeding a carbohydrate diet (without protein), the mRNA concentration was increased to the level in a carbohydrate/protein diet, while the enzyme induction was not so much increased. Dietary protein appeared to be involved in the translation.