糖脂質酵素モデル (第3報)
触媒活性に及ぼすベシクル膜の流動性の影響
1994 年 43 巻 8 号 p. 622-626
詳細
1994 年 43 巻 8 号 p. 622-626
Bis-quaternary ammonium salts (H25C12-CH3-N-CH3-CmH2m-CH3-N-CH3-C12H25 m : 220) were found to form vesicles as molecular aggregates. The vesicles were used as reaction media to evaluate the activity of a hydrolase model ; the hydrolysis of amino acid esters was carried out using a glycolipid as a model of α-chymotrypsin. Catalytic activity was affected by vesicle membrane fluidity and the addition of cholesterol caused the membrane to become somewhat rigid. Essentially the same is noted for reactions in a living system.
