Journal of Oral Science
Online ISSN : 1880-4926
Print ISSN : 1343-4934
Original
Effects of egg yolk antibody against Porphyromonas gingivalis gingipains in periodontitis patients
Kyosuke YokoyamaNaoyuki SuganoTeruko ShimadaRahman A. K. M. ShofiqurEl-Sayed M. IbrahimRie IsodaKouji UmedaNguyen Van SaYoshikatsu KodamaKoichi Ito
Author information
JOURNALS FREE ACCESS

2007 Volume 49 Issue 3 Pages 201-206

Details
Abstract

Porphyromonas gingivalis gingipains is suspected to be one of the most important causative agents of periodontitis. We postulated that the inhibition of gingipains may reduce the pathogenic nature of P. gingivalis. Anti-P. gingivalis egg yolk antibody (IgY-GP) was isolated from the yolks of hens immunized with purified gingipains. We applied IgY-GP gel subgingivally in periodontitis patients who harbored P. gingivalis in their subgingival flora. Five pairs of contralateral anterior single-rooted teeth were selected. One tooth in each contralateral pair was randomly treated with IgY-GP and subgingival scaling and root planing, whereas the other tooth was treated with SRP alone. The number of P. gingivalis bacteria was assessed by real-time PCR. Bacterial levels were expressed as the percentage of total bacteria. The IgY-GP group had a significant reduction in probing depth. BOP significantly decreased in the IgY-GP group compared to the control group at week 4. The levels of P. gingivalis significantly increased in the control group at week 4, whereas the reduction in the levels of P. gingivalis was sustained in the IgY-GP group. Within the limitations of the present study, IgY-GP was shown to be an effective immunotherapeutic agent in the treatment of periodontitis. (J. Oral Sci. 49, 201-206, 2007)

Information related to the author
© 2007 by Nihon University School of Dentistry
Previous article Next article
feedback
Top