Journal of Oral Science
Online ISSN : 1880-4926
Print ISSN : 1343-4934
Original
Polyacrylic resins regulate transcriptional control of interleukin-6, gp80, and gp130 genes in human gingival fibroblasts
Bruna BorelliFernando ZaroneVirginia RivieccioFrancesco RiccitielloMichele SimeoneRoberto SorrentinoSandro RengoGianrico SpagnuoloAlfredo Procino
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Volume 59 (2017) Issue 1 Pages 87-91

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Abstract

Studies have failed to identify the molecular mechanisms that regulate the genotoxic and cytotoxic effects of methacrylate resins, which are important in the biocompatibility of dental materials. Interleukin (IL)-6 has a crucial role in the control of acute-phase protein response during inflammation. In humans, the synthesis and release of two major acute-phase proteins, C-reactive protein and serum amyloid A, are regulated by IL-6. This study focused on IL-6 and activation of its receptors gp80 and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet Kit, Unifast, and Duralay on control of inflammation.

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© 2017 by Nihon University School of Dentistry
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