Journal of Oral Science
Online ISSN : 1880-4926
Print ISSN : 1343-4934
Review
Neural mechanisms of nociception during orthodontic treatment
Masayuki KobayashiEri Horinuki
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2017 Volume 59 Issue 2 Pages 167-171

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Abstract

Orthodontic tooth movement is accompanied by inflammatory responses in the periodontal ligament. Chemical mediators such as interleukin-1β have key roles in nociception around teeth. Such nociceptive inputs to the periodontal ligament continue for several days and potentially induce plastic changes in higher brain regions, including the cerebral cortex. This review summarizes research on orthodontic treatment-induced modulation of neural activities in the central nervous system. Furthermore, we describe our recent findings on the spatiotemporal effects of orthodontic treatment in the somatosensory and insular cortices.

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© 2017 by Nihon University School of Dentistry
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