The Journal of Nihon University School of Dentistry
Online ISSN : 1884-2984
Print ISSN : 0029-0432
ISSN-L : 0029-0432
Influences of Serine Protease Inhibitors on the Relaxation in Acetylcholine-Contracture of Anterior Byssal Retractor of Mytilus Edulis
村上 元石川 稔矩佐藤 達策
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1976 年 18 巻 4 号 p. 114-121

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The relaxing effects of protease inhibitors, EACA, PAB and aprotinin on the Ach-contracture of ABRM ofMytilus edulis were observed by measuring the half-relaxation time of Ach-contracture in comparison with the effects of serotonin and dopamine on it.
1. Serotonin and dopamine rapidly relaxed Ach-contracture of ABRM. These effects were dependent on the concentration of those two agents and consistent with those of other investigators.
2. EACA, PAB and aprotinin relaxed Ach-contracture of ABRM, and showed the lower potency as compared with serotonin and dopamine in relaxing action. These effects were dependent on the concentration of those agents by 10-4 M, respectively.
The significance of the results obtained was also discussed in relation to protease, contractile elements and elements maintaining prolonged contraction induced by Ach in ABRM.

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