The Journal of Nihon University School of Dentistry
Online ISSN : 1884-2984
Print ISSN : 0029-0432
ISSN-L : 0029-0432
Effect of Toxic Doses of Cholecalciferol (Vitamin D3) on Alkaline Phosphatase Levels in Serum and Gingival Tissues of Rats
Yegane GÜVENÇetin KASAPOGLUSami YILDIRIMOsman GÜMRÜ
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1990 年 32 巻 2 号 p. 77-80

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Toxic doses of cholecalciferol (vitamin D3) were injected subcutaneously (25μg/day) into rats for 5 weeks, causing a significant increase of serum alkaline phosphatase (ALP) levels (p < 0.01). Gingival tissue alkaline phosphatase levels were also elevated (p < 0.01). On the other hand, a significant difference was detected between serum calcium levels in experimental and control groups (p < 0.02).

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