1990 年 32 巻 2 号 p. 77-80
Toxic doses of cholecalciferol (vitamin D3) were injected subcutaneously (25μg/day) into rats for 5 weeks, causing a significant increase of serum alkaline phosphatase (ALP) levels (p < 0.01). Gingival tissue alkaline phosphatase levels were also elevated (p < 0.01). On the other hand, a significant difference was detected between serum calcium levels in experimental and control groups (p < 0.02).