Nickel based superalloy has excellent mechanical properties at high temperatures. The key factors gov-erning its elasto-plastic characteristics are supposed to be its microstructure, including misfit strain and nonuniform plastic deformation behavior of γ matrix. However, contribution of each factor to the overall elasto-plastic characteristics is not investigated quantitatively. In this paper, a series of numerical experi-ment by the homogenization method are therfore conducted on a few specific microstructures in order to clarify the elasto-plastic behavior of nickel based superalloy.