This paper described the use of a drone in collecting data and analyzing images for monitoring of rock slope. The drone consists of four electric rotors and equips with 4K camera. Firstly, the fundamental experiments were performed by the developed monitoring system with the drone. A measurement accuracy was discussed for method of collecting and using image data. As the results, it is made clear for obtaining a high measurement accuracy that the distance between slope surface and drone is less than 20m for collecting data, and that the overlap of images is 80%, and that GPS data and coordinates of GCP (Ground Control Point) are used in analyzing images. After that, the system was applied to rock slope of an open pit mine and a quarry. The three dimensional model can be constructed with a high accuracy. Furthermore, the change of shape of rock slope can be estimated with the lapse of time. Basing on these results, it is concluded that the developed system is very effective for monitoring rock slope.