Calcium-Channel Antagonists Inhibit Marble-Burying Behavior in Mice

Nobuaki Egashira; Ryoko Okuno; Moe Abe; Michihiko Matsushita; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Ryoji Nishimura; Yoshiaki Matsumoto; Michihiro Fujiwara

doi:10.1254/jphs.08160SC

Short Communications

Calcium-Channel Antagonists Inhibit Marble-Burying Behavior in Mice

Nobuaki Egashira, Ryoko Okuno, Moe Abe, Michihiko Matsushita, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Ryoji Nishimura, Yoshiaki Matsumoto, Michihiro Fujiwara

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Keywords: marble-burying behavior, calcium-channel antagonist, obsessive-compulsive disorder

JOURNAL FREE ACCESS

2008 Volume 108 Issue 1 Pages 140-143

DOI https://doi.org/10.1254/jphs.08160SC

View "Advance Publication" version (August 30, 2008).

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Abstract

In the present study, we examined the effects of calcium-channel antagonists on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Amlodipine (10 mg/kg, i.p.), cilnidipine (10 mg/kg, i.p.), nilvadipine (3 and 10 mg/kg, i.p.), and flunarizine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior in mice. These results suggest that calcium channels may be involved in the marble-burying behavior.

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