Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
Malignancy Grade–Dependent Expression of K+-Channel Subtypes in Human Prostate Cancer
Susumu OhyaKazunori KimuraSatomi NiwaAkitoshi OhnoYoshiyuki KojimaShoichi SasakiKenjiro KohriYuji Imaizumi
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2009 Volume 109 Issue 1 Pages 148-151

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Abstract

K+ channels are key molecules in the progression of several cancer types and considered to be potential targets for cancer therapy. We examined the gene expressions of voltage-gated (Kv), Ca2+-activated (KCa), and two-pore domain (K2P) K+-channel subtypes in needle-biopsy samples of human prostate cancer (PCa) by real-time PCR and compared them with those in PCa epithelial cell lines. The expression of Kv1.3, KCa1.1, KCa3.1, and K2P1 markedly increased in the PCa group with Gleason score of 5 – 6 (GS5–6) but significantly decreased in the GS8–9 group. This malignancy grade–dependent K+-channel expression pattern may provide a convenient marker to understand PCa progression level.

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© The Japanese Pharmacological Society 2009
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