Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
Intracerebroventricular Injection of Microglia Protects Against Focal Brain Ischemia
Yoshihisa KitamuraKazuyuki TakataMasatoshi IndenDaiju TsuchiyaDaijiro YanagisawaJunko NakataTakashi Taniguchi
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2004 Volume 94 Issue 2 Pages 203-206


Microglia are macrophage-like phagocytic cells in the brain parenchyma. However, microglial function after neurodegeneration is not fully understood. In this study, occlusion of the middle cerebral artery (MCA) and reperfusion caused massive neuronal loss in the rat cerebral cortex and striatum after 3 days. When exogenous microglia were microinjected into the intracerebroventricle during MCA occlusion, neurodegenerative areas significantly decreased. At that time, migrated microglia were detected in the ischemic lesion. These results suggest that exogenous microglia can migrate into brain parenchyma and then protect against neurodegeneration induced by MCA occlusion and reperfusion.

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© The Japanese Pharmacological Society 2004
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