Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
Captopril Enhances Cardiac Vagal but Not Sympathetic Neurotransmission in Pithed Rats
Yoshinobu TakataTakanori AraiShigeto SuzukiJunichi KuriharaTakashi UezonoYoko OkuboHitoshi Kato
Author information
JOURNALS FREE ACCESS

2004 Volume 95 Issue 3 Pages 390-393

Details
Abstract

The effect of captopril on neurally evoked bradycardia and tachycardia was investigated in pithed rats. Captopril enhanced the vagal nerve stimulation-evoked bradycardia. Angiotensin I reduced the vagal bradycardia, which was reversed by subsequent administration of captopril. Bradykinin did not affect the neurally evoked bradycardia. Captopril and angiotensin I affected neither the exogenous acetylcholine-evoked bradycardia nor the sympathetic nerve stimulation-evoked tachycardia. These results suggest that the interruption of angiotensin II formation by captopril causes less presynaptic inhibition of acetylcholine release via angiotensin II receptors without affecting cardiac sympathetic neurotransmission.

Information related to the author
© The Japanese Pharmacological Society 2004
Previous article Next article
feedback
Top