Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613

This article has now been updated. Please use the final version.

Inhibitory Effect of Cibenzoline on Na+/Ca2+ Exchange Current in Guinea-Pig Cardiac Ventricular Myocytes
Tomomi Yamakawa, Yasuhide Watanabe, Hiroshi Watanabe, Junko Kimura
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Keywords: antiarrhythmic drug, cibenzoline, Na+/Ca2+ exchange (NCX)
JOURNAL FREE ACCESS Advance online publication

Article ID: 12050SC

The final version of this article is now available: Vol. 120 (2012), No. 1 pp. 59-62
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Abstract

The effect of cibenzoline, a class I antiarrhythmic drug, on Na+/Ca2+ exchange current (INCX) was investigated using the patch-clamp method. Cibenzoline inhibited the bi-directional INCX in a concentration-dependent manner. The IC50 values of cibenzoline for the outward and inward components of INCX were 77 and 84 μM, respectively, with Hill coefficients of 1. Intracellular application of trypsin via the pipette solution did not change the inhibitory effect of cibenzoline. The inhibitory effect of cibenzoline on INCX at pHo 6.5 was smaller than those at pHo 7.4 and pHo 8.2. We conclude that cibenzoline inhibits INCX in supra-therapeutic concentrations.

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© 2012 The Japanese Pharmacological Society
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