EFFECT OF ANOXIA ON THE INTESTINAL MOTILITY RESPONSE TO NOREPINEPHRINE IN THE ISOLATED RABBIT ILEUM

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Acute anoxic conditions as seen frequently in circulatory and respiratory failures are almost always associated with release of catecholamines from the sympathetic nerve endings and/or adrenal medullas (1, 2). It has been known that catecholamines inhibit the intestinal motility of the isolated rabbit ileum (3-7), whereas anoxia increases the motility before complete paralysis (8-11). The present study was undertaken to investigate the effect of anoxia on the intestinal motility response to norepinephrine in the isolated rabbit ileum.