CHEMICAL CONSTITUTION AND DRUG ACTION OF N-SUBSTITUTED PHENOTHIAZINE IN VENTRICULAR ECTOPIC TACHYCARDIA

Abstract

Following the study of antiarrhythmic action of chlorpromazine by Arora and Madan (1, 2), Courvoisier et al. (3) and Burn (4), several others phenothiazine derivatives have been found to possess arrhythmia combating properties (1-10). The correlation of chemical structure with antiarrhythmic activity among phenothiazine derivatives has been studied by Sato et al. (9), and Singh and Sharma (10). In the present study, 10-N substituted phenothiazines have been examined in ventricular ectopic tachycardia and an attempt has been made to find the essential structural features responsible for antiarrhythmic activity.