A COMPARATIVE STUDY OF THE WRITHING RESPONSE INDUCED BY PHENYLQUINONE, BRADYKININ AND ACONITINE FOR THE ASSESSMENT OF ANALGESIC AGENTS

Abstract

Phenylquinone, bradykinin and aconitine induced writhing syndromes have been compared as to screening suitability for analgesic agents. It was observed that aconitine induced writhing appears more quickly, is more frequent and lasts for a longer period. Drug antagonism studies show that both phenylquinone and bradykinin induced writhing responses and are antagonised by antipyretics as well as narcotic analgesics, while aconitine induced writhing syndrome, is more selectively antagonised by the antipyretic analgesic agents.