STUDIES ON THE FUNCTION OF CELL MEMBRANE 4TH REPORT: ELECTRON MICROSCOPIC OBSERVATIONS ON CHANGES IN ULTRA-STRUCTURE OF LIVER CELL MEMBRANES IN CCl<SUB>4</SUB>-TREATED RATS

Ichiro YANO; Yasusuke MASUDA; Masato KUCHII; Hiroyuki YAMAMOTO; Tadashi MURANO

doi:10.1254/jjp.23.645

STUDIES ON THE FUNCTION OF CELL MEMBRANE

4TH REPORT: ELECTRON MICROSCOPIC OBSERVATIONS ON CHANGES IN ULTRA-STRUCTURE OF LIVER CELL MEMBRANES IN CCl₄-TREATED RATS

Ichiro YANO, Yasusuke MASUDA, Masato KUCHII, Hiroyuki YAMAMOTO, Tadashi MURANO

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JOURNAL FREE ACCESS

1973 Volume 23 Issue 5 Pages 645-652

DOI https://doi.org/10.1254/jjp.23.645

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Abstract

Morphological changes of liver cell membranes in CCl₄-administered rats were observed electronmicroscopically by using mainly a negative staining method. CCl₄ caused not only disappearance of elementary particles attached to the surface of cell membranes, but also that of hexagonal subunit patterns (treated with 1% DOC) in the membranes of tight junction 3-6 hr after administration. Present data indicates that CCl₄ primarily affects the plasma membrane rather than endoplasmic reticulum.

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