The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
STUDIES ON ANTITUMOR POLYSACCHARIDES, ESPECIALLY D-II, FROM MYCELIUM OF CORIOLUS VERSICOLOR
Mamoru SUGIURAHiroyuki OHNOMasahiro KUNIHISAFumio HIRATAHitoshi ITO
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1980 年 30 巻 4 号 p. 503-513

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A water-soluble polysaccharide, D-II with marked antitumor activity was isolated from the cultured mycelium of Coriolus versicolor by extraction with hot-water, fractional precipitation with ethanol and ion-exchange chromatography. D-II strongly inhibited the growth of Sarcoma-180 transplanted subcutaneously in mice by intraperitoneal, intravenous, subcutaneous or intra-muscular administration at a dose of 5 mg/kg. The molecular weight was estimated to be 2, 000, 000 by gel-filtration or 6, 500, 000 by light scattering analysis. The chemical structure of D-II was then investigated by periodate oxidation, methylation analysis, Smith degradation, and a combination of controlled Smith degradation and methylation analysis. These studies proposed that D-II is composed of a unit structure of four D-glucose residues, and is a glucan consisting of β-D-1, 3-linked main chain in which one for every three D-glucose residues is branched at C-6 with β-D-1, 6-linkage.

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