The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
β-Eudesmol (a Main Component of Atractylodes lancea)-Induced Potentiation of Depolarizing Neuromuscular Blockade in Diaphragm Muscles of Normal and Diabetic Mice
Masashi MUROIKatsunao TANAKAIkuko KIMURAMasayasu KIMURA
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1989 Volume 50 Issue 1 Pages 69-71

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Abstract

Potentiating effects of β-eudesmol on neuromuscular blockade were investigated in phrenic nerve-diaphragm muscles of normal and alloxan-diabetic mice. Pretreatment with β-eudesmol potentiated the blocking effects of succinylcholine to a greater extent in diabetic muscles than in normal ones. This effect was saturated after 30-min pretreatment in normal muscles. Further potentiation was observed after 60-min pretreatment in diabetic muscles. These results suggest that β-eudesmol modifies the sensitivity of diabetic mice to depolarizing blockers so that they have a higher susceptibility to these compounds.

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