ON THE VASODEPRESSIVE ACTION OF WARMED PLASMA IN CATS

Abstract

Much research has been made on the vasodepressive action of fresh defibrinated blood (1-5) and foreign serum (6-15). It is reported that histamine (16), acetylcholine (17), adenyl derivatives (18), etc., which contained blood, are the main substances, and furthermore that new substances as Kallikrein (19), substance P (20), substance Z (21), Felix-Lange's substance (22), Vesiglandin (23), and Bradykinin (24) which had their origin in living tissues brought down blood pressure.
Previously Hongo and Ueno (25) have found that an intravenous injection of plasma, warmed at 37°C for 18-24 hours, showed a transitorily marked hypotensive effect on the blood pressure of cats.
It is the purpose of this experiment to show that this active substance which appeared in the warmed plasma has been pharmacologically investigated, especially with regard to the mechanism of the vasodepressive effect.