細菌に対する二三シアニン色素の作用 第2報

抄録

(1) Cyanine dyes of ten different structures were tested for their antibacterial activities against various kinds of bacteria. It was found that they act strongly bactericidally against Gram positive bacteria but less strongly against Gram negative bacteria with the exception of Aer. aerogenes, H. pertussis and V. cholerae.
(2) Bactericidal activity of some of the cyanine dyes was found to be several hundred times as strong as that of mercurochrome or rivanol.
(3) Some of the cyanine dyes have induced, by contact with bacteria at a sublethal concentration, a strong resistance of V. cholerae against them, while S. aureus and B. sublilis showed only slight capacity of developing resistance against the same substance. The strain of V. cholerae which had become resistant against a cyanine dye was found to be non-resistant to mercurochrome and streptomycin, but decidedly resistant to other cyanine dyes, styryl dyes, acriflavine, crystal violet and methylene blue.
(4) Test with subcutaneous phagocytes of rabbit has revealed that the cytotoxicityof a cyanine dye was 100 times as strong as that of mercurochrome.
(5) Some of the cyanine dyes were found to have no cidal activity upon the intestinal parasite of toad (Rhabditis).