Twelve Renal Allotransplant in Pediatric Patients II Pathological Aspect

Abstract

Twelve kidneys transplanted into children from living related donors were examined for histo pathological deviations 1hr., Ca. 2 months and Ca. 1 year after the transplantation by use of light microscopy, electron microscopy and fluorescence techniques. 1. In kidneys examined 1hr. after the transplantation, 5 out of 12 cases showed some identifiable histological deviations which may have existed in the donor before the transplantation. 2. The influence of these changes on the clinical course after transplantion should be examined in the future. 3. Histological deviations compatible with acute rejection were observed even in cases which showed no apparent clinical episode of rejection. 4. Recovery from the histological deviations of rejection were observed in accordance with the clinical recovery from rejection. 5. Electron microscopic findings of transplant glomerulopathy were observed in the glomerulus of cases which had reccurent episodes of rejection. 6. By fluorescence techniques, IgC, IgM, and .A1C were seen in many cases. 7. To date, we have seen no cases of reccurence of the original glomerular diseases.