抄録
The effects of metoclopramide (MP), a dopaminergic inhibitor, on aldosterone (PAC), prolactin (PRL), cortisol (PF) and renin activity (PRA) in plasma and serum potassium (sK) and sodium (sNa) were evaluated in normal human subjects treated with dexamethasone (2 mg daily for 2 days). MP increased PAC from a baseline of 9.7±3.3 (mean±s. e.) to 12.7±4.4, 16.6±6.3, 17.1±5.9 (p<0.05), 15.7±5.7, 14.6±5.0 and 12.0±3.8 ng/dl at 5, 15, 30, 60, 90 and 120 min after MP administration, respectively. PRL was also increased by MP administration from a baseline of 4.8±2.5 to 35.0±3.4 (p<0.001), markedly to 84.3±9.4 (p<0.001), 80.5±5.5 (p<0.001), 70.0±5.5 (p<001) and 63.8±4.8 (p<0.001) ng/ml at 5, 15, 30, 60, 90 and 120 min after MP, respectively. On the other hand, PF, which was markedly lowered from a control of 6.3±2.5 to 0.34±0.11 (p<0.001) μg/dl with dexamethasone administration, did not change with MP infusion. Both sK and sNa did not change with MP administration. There was no significant correlation between changes in PAC and PRA at each time after MP administration. Also there was no significant correlation between changes in PAC and in PRL at each time after MP administration. These results suggest that MP increases plasma aldosterone independently of renal and pituitary mediations in normal man.
